Application | Comment | Organism |
---|---|---|
medicine | patient study, patients with testicular germ-cell cancer treated with bleomycin-containing chemotherapy, response to chemotherapy determined by gene polymorphisms involved in metabolism of cytotoxic drugs analyzed, importance for risk classification and selection for alternative treatment strategies suggested | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13867 | encoded by Blmh gene; patient study, testicular germ-cell cancer | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
germ cell cancer cell | testicular germ-cell cancer, response to chemotherapy dependent on gene polymorphism of bleomycin hydrolase analyzed | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
response to chemotherapy dependent on gene polymorphism of bleomycin hydrolase analyzed, homozygous variant G/G of bleomycin hydrolase gene SNP A1450G associated with reduced survival and higher prevalence of early relapses in testicular germ-cell cancer patients treated with bleomycin-containing chemotherapy | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | bleomycin hydrolase as an essential component of chemotherapy regimens for disseminated testicular germ-cell cancer analyzed, study on relation of single nucleotide polymorphism (SNP) A1450G of the bleomycin hydrolase gene with survival according to genotype analyzed | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BLMH protein | - |
Homo sapiens |